There are 1 repository under hiv topic.
Source files for building the IDM EMOD disease transmission model.
The Visualization Multitool for Molecular Epidemiology and Bioinformatics
Network Models of HIV Transmission Dynamics among MSM and Heterosexuals
The Visualization Multitool for Molecular Epidemiology and Bioinformatics
The diversity of RNA structural elements and their documented role in human diseases make RNA an attractive therapeutic target. However, progress in drug discovery and development has been hindered by challenges in the determination of high-resolution RNA structures and a limited understanding of the parameters that drive RNA recognition by small molecules, including a lack of validated quantitative structure-activity relationships (QSAR). Herein, we developed QSAR models that quantitatively predict both thermodynamic and kinetic-based binding parameters of small molecules and the HIV-1 TAR model system. Small molecules bearing diverse scaffolds was screened against the HIV-1 TAR using surface plasmon resonance. Then multiple linear regression (MLR) combined with feature selection was performed to afford robust models that allowed direct interpretation of properties critical for both binding strength and kinetic rate constants. These models were externally validated with new molecules and their accurate performance confirmed via comparison to ensemble tree methods.
Clinical Trial Risk Tool for analysing clinical trial protocols using natural language processing and assessing the risk of ending uninformatively, developed by Fast Data Science
a platform for the collection, storage, retrieval, and analysis of experimental data for laboratory workflows
A repository for the Advanced Programming Tutorial that teaches you how to develop an interactive model using Shiny
This repo contains the data and software used to run the analyses in the "Using machine learning and Big data to explore the drug resistance landscape in HIV"
Viral Load Sample Management - Machine Interfacing
Reconstruction and analysis of the HIV outbreak in Scott County, Indiana
A toolkit for creating databases of viral integration sites in host genomes
High accuracy single molecule Nanopore reads using the MrHAMER pipeline
Tutorial materials as referenced in IDM's documentation for EMOD, an agent-based disease dynamics model.
Codes for the identification of HIV predictors by Machine Learning Techniques.
The classification, structure and replication cycle of HIV, its effect on the infected host cell (Helper T-cell) and on the infected organism (AIDS).
Scripts and outputs for the paper "Signature changes in gut microbiome are associated with increased susceptibility to HIV-1 infection in MSM"
Scripts and outputs for the manuscript "The effect of sexual behavior on HIV-1 seroconversion is mediated by the gut microbiome and proinflammatory cytokines"
SEEPS: Sequence Evolution and Epidemiological Process Simulator
This repository will used to gather and distribute intelligence about the The AIDS-cure Genocide started by Gilead Sciences which includes the CIA's massacres of houses of worship.
I created various dashboards to ascertain (a)Prevalence of all forms of TB across various countries divided into 6 regions, (b)Distribution of mortality, (c) Evaluation of Mortality (d)Comorbidities with HIV
Code repository for the publication. Contains Monolix and Julia files used for parameter estimation and figure generation, respectively.