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GEMINI: A variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens
Computational approach to identify Survival associated Pairwise Gene Expression states.
A genetic study of the allele- and tissue- specific interactions of the KRAS alleles.
The functional analysis of genes provides relevant information to understand cellular function. Further, the mapping of genetic interactions sheds light on how genes act in the emergence of cellular complexity. Here, we present the most extensive genetic interaction and morphological profiling screen in a metazoan cell to date. We profiled 680 000 pairwise RNAi perturbations in more than 38 billion cells and analyzed 73 morphological features by high-throughput imaging.
Supporting material for upcoming manuscript on KMT2D in silico genetic networks