Manta: An In-Situ Debugging Tool for Programmable Hardware
Manta is a tool for getting information into and out of FPGAs over an interface like UART or Ethernet. It's primarily intended for debugging, but it's robust enough to be a simple, reliable transport layer between a FPGA and a host machine. It lets you configure a series of cores on a shared bus via a YAML or JSON file, and then provides a Python API to each core, along with vendor-agnostic Verilog HDL to instantiate them on your FPGA.
For more information check out the docs: https://fischermoseley.github.io/manta