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Taking causal inference to the extreme!
Targeted maximum likelihood estimation (TMLE) enables the integration of machine learning approaches in comparative effectiveness studies. It is a doubly robust method, making use of both the outcome model and propensity score model to generate an unbiased estimate as long as at least one of the models is correctly specified.
The R package trajmsm is based on the paper Marginal Structural Models with Latent Class Growth Analysis of Treatment Trajectories: https://doi.org/10.48550/arXiv.2105.12720.
This paper uses g-computation to estimate the effect of long-term exposure to air-pollution on mortality
R code for the analyses conducted in Friedrich, S & Friede, T (2020). Causal inference methods for small non-randomized studies: Methods and an application in COVID-19. Submitted to Contemporary Clinical Trials.