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Comparative homology modelling of SARSCov2 NSP4 subregion using Modeller

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Modeller

Comparative Homology Modelling of SARSCov2 NSP4 region

Steps implemented in NSP4_structure.ipynb:

  1. PSI-BLAST to find homologous sequence
  2. Refining the target-template alignment
  3. Constructing the model by satisfying spatial restraints
  4. Evaluating model (and template) by generating DOPE profile
  5. Visualizing modelled structure
  6. Visualizing DOPE profiles of model and template

Submitted as an assignment for M. S. Madhusudhan's Bioinformatics course at IISER Pune.

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Comparative homology modelling of SARSCov2 NSP4 subregion using Modeller


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