lauramedlock / SFO-model

SFO Neuron Model from Medlock et al. 2018

Home Page:https://journals.physiology.org/doi/full/10.1152/jn.00340.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Geek Repo:Geek Repo

Github PK Tool:Github PK Tool

SFO Neuron Model

Tonic and burst firing SFO model as published in JNeurophysiology:

Medlock L, Shute L, Fry M, Standage D, Ferguson AV. Ionic mechanisms underlying tonic and burst firing behavior in subfornical organ neurons: a combined experimental and modeling study. J Neurophysiol. 2018 Nov 1;120(5):2269-2281.

Extra Code:

sfo-ang-tnf-kca --> replaced the IKS current in the original SFO model with a calcium-dependent K+ current (IKCA)

presented at Canadian Association for Neuroscience (CAN) 2018

sfo-svm-classifier --> support vector machine that allows you to predict whether an SFO neuron will respond to ANG-II

presented in Computational Neuroscience Keystone Project (Queen's University, 2018)