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kassambara / survminer

Survival Analysis and Visualization

Home Page:https://rpkgs.datanovia.com/survminer/

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survminer: Survival Analysis and Visualization

The survminer R package provides functions for facilitating survival analysis and visualization.

The main functions, in the package, are organized in different categories as follow.

Survival Curves


  • ggsurvplot(): Draws survival curves with the ‘number at risk’ table, the cumulative number of events table and the cumulative number of censored subjects table.

  • arrange_ggsurvplots(): Arranges multiple ggsurvplots on the same page.

  • ggsurvevents(): Plots the distribution of event’s times.

  • surv_summary(): Summary of a survival curve. Compared to the default summary() function, surv_summary() creates a data frame containing a nice summary from survfit results.

  • surv_cutpoint(): Determines the optimal cutpoint for one or multiple continuous variables at once. Provides a value of a cutpoint that correspond to the most significant relation with survival.

  • pairwise_survdiff(): Multiple comparisons of survival curves. Calculate pairwise comparisons between group levels with corrections for multiple testing.


Diagnostics of Cox Model


  • ggcoxzph(): Graphical test of proportional hazards. Displays a graph of the scaled Schoenfeld residuals, along with a smooth curve using ggplot2. Wrapper around plot.cox.zph().

  • ggcoxdiagnostics(): Displays diagnostics graphs presenting goodness of Cox Proportional Hazards Model fit.

  • ggcoxfunctional(): Displays graphs of continuous explanatory variable against martingale residuals of null cox proportional hazards model. It helps to properly choose the functional form of continuous variable in cox model.


Summary of Cox Model


  • ggforest(): Draws forest plot for CoxPH model.

  • ggcoxadjustedcurves(): Plots adjusted survival curves for coxph model.


Competing Risks


  • ggcompetingrisks(): Plots cumulative incidence curves for competing risks.

Find out more at https://rpkgs.datanovia.com/survminer/, and check out the documentation and usage examples of each of the functions in survminer package.

Installation and loading

Install from CRAN as follow:

install.packages("survminer")

Or, install the latest version from GitHub:

if(!require(devtools)) install.packages("devtools")
devtools::install_github("kassambara/survminer", build_vignettes = FALSE)

Load survminer:

library("survminer")

ggsurvplot: Drawing survival curves

Fitting survival curves

require("survival")
fit <- survfit(Surv(time, status) ~ sex, data = lung)

Basic plots

ggsurvplot(fit, data = lung)

Censor shape can be changed as follow:

ggsurvplot(fit, data = lung, censor.shape="|", censor.size = 4)

Customized survival curves

ggsurvplot(
  fit, 
  data = lung, 
  size = 1,                 # change line size
  palette = 
    c("#E7B800", "#2E9FDF"),# custom color palettes
  conf.int = TRUE,          # Add confidence interval
  pval = TRUE,              # Add p-value
  risk.table = TRUE,        # Add risk table
  risk.table.col = "strata",# Risk table color by groups
  legend.labs = 
    c("Male", "Female"),    # Change legend labels
  risk.table.height = 0.25, # Useful to change when you have multiple groups
  ggtheme = theme_bw()      # Change ggplot2 theme
)

Note that, additional arguments are available to customize the main title, axis labels, the font style, axis limits, legends and the number at risk table.

More customized survival curves

Focus on xlim and break.time.by parameters which do not change the calculations of estimates of survival surves. Also note risk.table.y.text.col = TRUE and risk.table.y.text = FALSE that provide bars instead of names in text annotations of the legend of risk table.

ggsurvplot(
   fit,                     # survfit object with calculated statistics.
   data = lung,             # data used to fit survival curves.
   risk.table = TRUE,       # show risk table.
   pval = TRUE,             # show p-value of log-rank test.
   conf.int = TRUE,         # show confidence intervals for 
                            # point estimates of survival curves.
   xlim = c(0,500),         # present narrower X axis, but not affect
                            # survival estimates.
   xlab = "Time in days",   # customize X axis label.
   break.time.by = 100,     # break X axis in time intervals by 500.
   ggtheme = theme_light(), # customize plot and risk table with a theme.
 risk.table.y.text.col = T, # colour risk table text annotations.
  risk.table.y.text = FALSE # show bars instead of names in text annotations
                            # in legend of risk table
)

Uber customized survival curves

ggsurv <- ggsurvplot(
           fit,                     # survfit object with calculated statistics.
           data = lung,             # data used to fit survival curves.
           risk.table = TRUE,       # show risk table.
           pval = TRUE,             # show p-value of log-rank test.
           conf.int = TRUE,         # show confidence intervals for 
                                    # point estimates of survival curves.
           palette = c("#E7B800", "#2E9FDF"),
           xlim = c(0,500),         # present narrower X axis, but not affect
                                    # survival estimates.
           xlab = "Time in days",   # customize X axis label.
           break.time.by = 100,     # break X axis in time intervals by 500.
           ggtheme = theme_light(), # customize plot and risk table with a theme.
          risk.table.y.text.col = T,# colour risk table text annotations.
          risk.table.height = 0.25, # the height of the risk table
          risk.table.y.text = FALSE,# show bars instead of names in text annotations
                                    # in legend of risk table.
          ncensor.plot = TRUE,      # plot the number of censored subjects at time t
          ncensor.plot.height = 0.25,
          conf.int.style = "step",  # customize style of confidence intervals
          surv.median.line = "hv",  # add the median survival pointer.
          legend.labs = 
            c("Male", "Female")    # change legend labels.
        )
ggsurv

Uber platinum customized survival curves

Helper function to customize plot labels:

customize_labels <- function (p, font.title = NULL,
                              font.subtitle = NULL, font.caption = NULL,
                              font.x = NULL, font.y = NULL, font.xtickslab = NULL, font.ytickslab = NULL)
{
  original.p <- p
  if(is.ggplot(original.p)) list.plots <- list(original.p)
  else if(is.list(original.p)) list.plots <- original.p
  else stop("Can't handle an object of class ", class (original.p))
  .set_font <- function(font){
    font <- ggpubr:::.parse_font(font)
    ggtext::element_markdown (size = font$size, face = font$face, colour = font$color)
  }
  for(i in 1:length(list.plots)){
    p <- list.plots[[i]]
    if(is.ggplot(p)){
      if (!is.null(font.title)) p <- p + theme(plot.title = .set_font(font.title))
      if (!is.null(font.subtitle)) p <- p + theme(plot.subtitle = .set_font(font.subtitle))
      if (!is.null(font.caption)) p <- p + theme(plot.caption = .set_font(font.caption))
      if (!is.null(font.x)) p <- p + theme(axis.title.x = .set_font(font.x))
      if (!is.null(font.y)) p <- p + theme(axis.title.y = .set_font(font.y))
      if (!is.null(font.xtickslab)) p <- p + theme(axis.text.x = .set_font(font.xtickslab))
      if (!is.null(font.ytickslab)) p <- p + theme(axis.text.y = .set_font(font.ytickslab))
      list.plots[[i]] <- p
    }
  }
  if(is.ggplot(original.p)) list.plots[[1]]
  else list.plots
}

Customized plot labels:

# Changing Labels
# %%%%%%%%%%%%%%%%%%%%%%%%%%
# Labels for Survival Curves (plot)
ggsurv$plot <- ggsurv$plot + labs(
  title    = "Survival curves",                     
  subtitle = "Based on Kaplan-Meier estimates",  
  caption  = "created with survminer"             
  )

# Labels for Risk Table 
ggsurv$table <- ggsurv$table + labs(
  title    = "Note the risk set sizes",          
  subtitle = "and remember about censoring.", 
  caption  = "source code: website.com"        
  )

# Labels for ncensor plot 
ggsurv$ncensor.plot <- ggsurv$ncensor.plot + labs( 
  title    = "Number of censorings", 
  subtitle = "over the time.",
  caption  = "source code: website.com"
  )

# Changing the font size, style and color
# %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
# Applying the same font style to all the components of ggsurv:
# survival curves, risk table and censor part

ggsurv <- customize_labels(
  ggsurv,
  font.title    = c(16, "bold", "darkblue"),         
  font.subtitle = c(15, "bold.italic", "purple"), 
  font.caption  = c(14, "plain", "orange"),        
  font.x        = c(14, "bold.italic", "red"),          
  font.y        = c(14, "bold.italic", "darkred"),      
  font.xtickslab = c(12, "plain", "darkgreen")
)

ggsurv

Uber platinum premium customized survival curves

# Using specific fonts for risk table and ncensor plots
#%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
# Font for Risk Table
ggsurv$table <- customize_labels(
  ggsurv$table,
  font.title    = c(13, "bold.italic", "green"),
  font.subtitle = c(15, "bold", "pink"),
  font.caption  = c(11, "plain", "darkgreen"),
  font.x        = c(8, "bold.italic", "orange"),
  font.y        = c(11, "bold.italic", "darkgreen"),
  font.xtickslab = c(9, "bold", "red")
)


# Font for ncensor plot
ggsurv$ncensor.plot <- customize_labels(
  ggsurv$ncensor.plot,
  font.title    = c(13, "bold.italic", "green"),
  font.subtitle = c(15, "bold", "pink"),
  font.caption  = c(11, "plain", "darkgreen"),
  font.x        = c(8, "bold.italic", "orange"),
  font.y        = c(11, "bold.italic", "darkgreen"),
  font.xtickslab = c(9, "bold", "red")
)

print(ggsurv)

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Survival Analysis and Visualization

https://rpkgs.datanovia.com/survminer/

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