Drug Loaded Nanoparticles
PBPK Modeling For Therapeutic Nanoparticles Loaded With Drug
This repository includes the model reproduced from the the paper and datasets from figures and the supplementary materials:
Shalgunov et al. Comprehensive study of the drug delivery properties of poly(l-lactide)-poly(ethylene glycol) nanoparticles in rats and tumor-bearing mice. 2017 Journal of Controlled Release 261. DOI: 10.1016/j.jconrel.2017.06.006
Known restrictions
- "Units inconsistency" messages for some records:
v,vrelbecause of limited support of fractional units in Heta. But this doesn't affect simulation results.
Diagnostics
The original model and parameters
Simulated vs measured dependence of average VCR concentration for the NP of type U16c.
You find other diagnostic plots in the directory /diagnostics/reproduced model/
Reproduced in HetaSimulator.jl and fitted
Exported formats
See dist branch
TODO
- Simulations and experimental data in HetaSimulator
- Share the datasets
- Reproduce fitting
Contributors
Evgeny Metelkin is the author of the Heta-based modeling code.
The model and data in the study were reproduced from the published study. The authors of the original study are: V. Shalgunov, D. Zaytseva-Zotova, A. Zintchenko, T. Levada, Y. Shilov, D. Andreyev, D. Dzhumashev, E. Metelkin, A. Urusova, O. Demin, K. McDonnell, G. Troiano, S. Zale, E. Safarovа