TheJacksonLaboratory / mia-sig

Multiplex chromatin interaction analysis by signal processing and statistical algorithms

MIA-Sig

MIA-Sig is designed to 'extract true signal' in multiplex chromatin interaction data by filtering out noise.

It has been tested on ChIA-Drop and RNAPII ChIA-Drop (Zheng et al., 2019) data, and can potentially be applied to GAM (Beagrie et al., 2017) and SPRITE (Quinodoz et al., 2018) data.

Documentation

Visit our Wiki pages.

Get started

1. Install dependencies.
2. Set up MIA-Sig.
3. Follow tutorials to run test datasets.

• ChIA-Drop data
• RNAPII ChIA-Drop data

4. Use MIA-Sig in your own projects.

Bug reports

To report bugs, contact Minji ([e-mail]) or visit the Issues page.