PNNL-Comp-Mass-Spec / LINCS-Finder

a web app to find the most interesting signatures from LINCS L1000

LINCS-Finder: a Python web app for finding LINCS signatures

This is a web application to quickly find the most interesting LINCS signatures. It's based on Blazing Signature Filter (BSF) behind. Please refer to https://github.com/PNNL-Comp-Mass-Spec/bsf-py/ for details.

How to run

We provide a docker version for this application. Please refer to these following steps to run this app on your local machine.

1. Install the latest docker in your machine. Please refer to https://docs.docker.com/engine/installation/.
2. Pull the LINCS Finder image.

docker pull coldfire79/lincs-finder

3. Run the LINCS Finder image.

docker run -p 127.0.0.1:8081:8081 -it --name lincs-finder coldfire79/lincs-finder

3. Go to 'http://localhost:8081/'

How to use

Please submit your own list of genes into corresponding text boxes to query the similar signatures. Then, click the Submit button.

How to open KEGG pathways

For example, http://localhost:8081/pathway.html?id=hsa05145&nodes=LJP005_A375_24H:G01. You can try to open your own links to display a KEGG pathway of interest as follows: localhost:8081/pathway.html?id=<KEGG ID>&nodes=<LINCS ID>.