Open-Systems-Pharmacology / Tacrolimus-Model

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Tacrolimus-Model

Modeling of published clinical tacrolimus studies for model evaluation

Repository files

Within this repository, we distribute a whole-body PBPK model for tacrolimus. The model was developed using published clinical studies and its predictive performance was evaluated within our DDGI network. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation, please refer to [1].

Version information

PK-Sim Version 10.

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model is distributed under the GPLv2 Lincense.

Reference

[1] Loer HLH, Feick D, Rüdesheim S, Selzer D, Schwab M, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Lehr T. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol 2023;00:1-15.