Open Systems Pharmacology

PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

MoBi

MoBi® is a software tool for multiscale physiological modeling and simulation

OSPSuite-R

R package for the OSPSuite

TLF-Library

TLF Library implementation in R

Digoxin-Model

Whole-body PBPK model of digoxin as P-gp DDI victim drug

Pregnancy-Models

Physiologically Based Pharmacokinetic Models for Pregnant Women

OSPSuite.Core

Core functionalities of the Open Systems Pharmacology Suite

Database-for-observed-data

Database for published pharmacokinetic data

OSPSuite.ReportingEngine

R implementation of the reporting engine

OSPSuite.SimModel

Calculation engine for models built with PK-Sim® or MoBi®

OSPSuite.ParameterIdentification

R package for parameter identification for OSPS models

OSPSuite.Plots

Figures and dependent tables which are used by R packages in the Open Systems Pharmacology ecosystem

InstallationValidator

Installation Validation Tool for the Open Systems Pharmacology Suite

open-systems-pharmacology.github.io

Open Systems Pharmacology Website (www.open-systems-pharmacology.org)

OSPSuite.RUtils

Utility functions for Open Systems Pharmacology R packages

OSPSuite.TeXReporting

LaTeX Reporting Component for the Open Systems Pharmacology Suite

Ruxolitinib-Model

Workflows

Reusable workflows (e.g. GitHub Actions) which can be used in any OSP repository

OSPSuite.GlobalSensitivity

Clarithromycin-Digoxin-DDI

Modeling of published clinical Clarithromycin-Digoxin-DDI studies for model evaluation

developer-docs

OSMOSES

Open-Source MOdeling framework for automated quality control and management of complex life Science systEms modelS (OSMOSES)

OSPSuite.FuncParser

Function parser for numeric and logic expressions used by the Open Systems Pharmacology Suite

OSPSuite.SimModel.Solver.CVODES

ODE solver used by OSPSuite.SimModel. Based on CVODES solver (Copyright © 2002-2018, Lawrence Livermore National Security)

OSPSuite.SimModelSolverBase

Base implementation for all solver used by OSPSuite.SimModel

Paroxetine-Model

Pitavastatin-Model

RE-Test-Reports

Assess consistency of simple reports generated using `{ospsuite.reportingengine}` package

Rifampicin-Model

Whole-body PBPK model of rifampicin as CYP3A4 and P-gp DDI perpetrator drug

Roadmap

Roadmap for the Open Systems Pharmacology Platform