Open-Systems-Pharmacology / Pediatric_Qualification_Package_UGT1A9_Ontogeny

Pediatric Qualification Package for UGT1A9 Ontogeny

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Pediatric Qualification Package for UGT1A9 Ontogeny

In this repository the electronic package for qualification of UGT1A9 ontogeny using in vivo probe substances are stored, including

  • Input files (qualification plan, report text modules and observed data)
  • Qualification Report

For the Qualification of the UGT1A9 mediated elimination of compounds, the following probe substance was included:

  • Propofol [1]

Necessary software to execute the qualification workflow (see http://setup.open-systems-pharmacology.org for download links and instructions):

  • QualificationRunner
  • Reporting-Engine
  • Markdown-joiner

References

[1] Propofol-Model, Whole-body PBPK model of Propofol.

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Pediatric Qualification Package for UGT1A9 Ontogeny


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