Open-Systems-Pharmacology / Pediatric_Qualification_Package_CYP2C8_Ontogeny

Pediatric Qualification Package for CYP2C8 Ontogeny

Pediatric Qualification Package for CYP2C8 Ontogeny

In this repository the electronic package for qualification of CYP2C8 ontogeny using in vivo probe substances are stored, including

• Input files (qualification plan, report text modules and observed data)

For the Qualification of the CYP2C8 mediated elimination of compounds, the following probe substance was included:

• Montelukast [1]

Necessary software to execute the qualification workflow (see http://setup.open-systems-pharmacology.org for download links and instructions):

• QualificationRunner
• Reporting-Engine
• Markdown-joiner

References

[1] Montelukast-Model, Whole-body PBPK model of Montelukast.