Whole-body PBPK model of Levonorgestrel as well as ethinyl estradiol
This repository contains:
- a PK-Sim project (*.pksim5) file of the current PBPK model(s)
This levonogrestrel model is intended to be used as victim drug in CYP3A4-mediated drug-drug interactions (DDI) when orally administered either alone or in combination with ethinyl estradiol in healthy and obese women.
The model incorporates dynamic changes in SHBG protein-binding, via an Emax model, observed during long-term use of levonogrestrel and ethinyl estradiol.
The presented model represents an original model development project presented by Cicali et al. [1]. A complete summary of model development and application can be found in this manuscript and respective supplemental materials.
Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.
We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.
The model code is distributed under the GPLv2 License.
[1] [Cicali, B. et al. Quantitative assessment of levonorgestrel binding partner interplay and drug-drug interactions using physiologically based pharmacokinetic modeling. CPT:Pharmacometrics and Systems Pharmacology. accepted (2020).]