Modeling of published clinical ketoconazole-alfentanil DDI studies for model evaluation
Within this repository, we distribute a PK-Sim project file containing simulations of the published clinical studies used to evaluate the predictive performance of the ketoconazole model [1] regarding the DDI with the CYP3A4 victim drug alfentanil, including the respective observed data digitized from literature reports. The applied alfentanil model has been published previously [2]. For further details and documentation please refer to [1].
PK-Sim Version 11.0.
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The model is distributed under the GPLv2 Lincense.