LMD is a computational framework designed for the identification of gene expression markers localized to specific cell populations within single-cell RNA sequencing data.
Get started with LMD by exploring our mouse bone marrow example.
Demo_marrow_facs.Rmd: A demonstration file showcasing how to apply LMD on a mouse bone marrow dataset.Marker_identfication_benchmark.Rmd: Utilize this file to reproduce the benchmark results presented in our study, comparing LMD's performance against other methods.paper_figure.Rmd: This file includes the necessary data to reproduce the figures in our publication.Module_Description.xlsx: This xlsx file provides detailed descriptions of gene modules identified by LMD, including module IDs, gene lists, associated cell types, and the top 5 most significantly enriched GO terms and pathways for each module.