Allow `Tumor` nodes to have states (aka T-categories) as well
rmnldwg opened this issue · comments
Given our new implementation of the graph representation and particularly the Tumor
node implementation, it should be straightforward to enable tracking a tumor's T-category as a random variable:
We basically need to give the Tumor
node the allowed_states = [0, 1, 2, 3, 4]
and add an Edge
instance that has this Tumor
node both as start and as end (similar to the growth edges). This edge would then be parametrized with a probability that during one time-step the T-category increases by one.
If then functions like the generate_transition()
don't just iterate over LNLs, but over all nodes and consider their possible evolutions, this Tumor
node's state would be automatically incorporated and tracked as a random variable, just like all other LymphNodeLevel
node's states.
When tracking T-category as a random variable, the distributions over diagnose times make no sense anymore and we would need to define a "diagnosis probability" that depends on all the node's states. We discussed this idea already.