phyx performs phylogenetics analyses on trees and sequences. See installation instructions for Linux and Mac including any dependencies on the wiki here or below. A list of the current programs with examples can be found here.

Authors: Joseph W. Brown, Joseph F. Walker, and Stephen A. Smith

Citation: Brown, J. W., J. F. Walker, and S. A. Smith; Phyx: phylogenetic tools for unix. Bioinformatics 2017; 33 (12): 1886-1888. doi: 10.1093/bioinformatics/btx063

License: GPL https://www.gnu.org/licenses/gpl-3.0.html

Some of the sequence comparison operations use the very nice edlib library. These are reported in this publication: Martin Šošić, Mile Šikić; Edlib: a C/C ++ library for fast, exact sequence alignment using edit distance. Bioinformatics 2017 btw753. doi: 10.1093/bioinformatics/btw753.

Installation instructions

phyx requires a few dependencies. Since installation of these dependencies differs on Linux vs. Mac OSX, we've separated the instructions below.

Mac install

Mac has become increasingly difficult to support at the command line with changes every version on location and standards for compilation tools. First, distribution of compiled programs is very difficult. Furthermore, Mac now defaults to clang as a C/C++ compiler, which does not support OpenMP. For Mac OSX 10.12, we have found that you can install with clang using the simple instructions and [homebrew] (http://brew.sh/) or using a fresh installation of gcc from here. Instructions for both are below (don't use both, choose one, probably the simple one). For simple instructions click here, and for advanced instructions click here.

Install with Homebrew (simple instructions)

The instructions below assume homebrew, which is convenient for dealing with dependencies.

Install the homebrew package manager:

 /usr/bin/ruby -e "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/install)"

Install dependencies from homebrew:

 brew install git
 brew install cmake
 brew install homebrew/science/nlopt

In recent versions armadillo from brew works best:
```
 brew install armadillo
```

On to phyx. first, clone the repository (if you haven't already):
```
 git clone https://github.com/FePhyFoFum/phyx.git
```
Install the final dependency, armadillo, (included with phyx):

This can be installed from the deps or from brew:

 cd phyx/deps
 tar -xzf armadillo-7.400.2.tgz
 cd armadillo-7.400.2
 ./configure
 make
 sudo make install

If you install from brew, you can do this by

 brew install homebrew/science/nlopt
 export CXX=/usr/local/bin/g++-6

Install phyx

 cd ../../src
 ./configure
 make
 python run_tests.py

If you want to install it so it is available anywhere in your system, do:

    sudo make install

Install with HPC GCC (advanced instructions)

Install gcc and gfortran. Download gcc-6.2-bin.tar.gz or more recent from http://hpc.sourceforge.net/. Install with:
```
 sudo tar -xvf gcc-6.2-bin.tar -C /
```

Install autoconf from http://ftp.gnu.org/gnu/autoconf/. Get autoconf-latest.tar.gz, then:

 tar -xzf autoconf-latest.tar.gz
 cd autoconf-2.69
 ./configure --prefix=/usr/local/autoconf-2.69
 make
 sudo make install
 ln -s autoconf-2.69 /usr/local/autoconf

On to phyx. first, clone the repository (if you haven't already):
```
 git clone https://github.com/FePhyFoFum/phyx.git
```
Install cmake and install Armadillo. Get cmake from https://cmake.org/download/. I got https://cmake.org/files/v3.6/cmake-3.6.2-Darwin-x86_64.tar.gz. Get armadillo from the deps directory or http://arma.sourceforge.net/download.html, get the stable one. Untar it. Double click the Cmake.app. Click "Browse source..." and choose the armadillo folder that was created after untaring. Click "Browse build..." and choose the same folder as browse source. Click "Configure" and then click "Generate". Go to the terminal and browse to that armadillo folder and type:
```
 make
 sudo make install
```
Install nlopt. Get armadillo from the deps directory or go to http://ab-initio.mit.edu/wiki/index.php/NLopt#Download_and_installation and download the latest (probably nlopt-2.4.2.tar.gz). Untar and browse in the terminal to that directory:
```
 ./configure --with-cxx --without-octave --without-matlab
 make
 sudo make install
```
Compile phyx. Now you can go to the src directory of phyx and type:
```
 ./configure
 make
 python run_tests.py
 sudo make install
```

and all the programs should compile without issue.

Linux install

These instructions work for most ubuntu versions as well as debian.

Install general dependencies:

 sudo apt-get install git
 sudo apt-get install autotools-dev
 sudo apt-get install autoconf
 sudo apt-get install automake
 sudo apt-get install cmake
 sudo apt-get install libtool
 sudo apt-get install liblapack-dev
 sudo apt-get install libatlas-cpp-0.6-dev

Clone the phyx repo (if you haven't already):

 git clone https://github.com/FePhyFoFum/phyx.git

Install nlopt dependency (default is C, we need C++; not available from apt-get):

 cd phyx/deps
 tar -xvzf nlopt-2.4.2.tar.gz
 cd nlopt-2.4.2
 ./configure --with-cxx --without-octave --without-matlab
 make
 sudo make install

Install armadillo dependency
Note: it is possible to get from apt-get, but need version >= 5.2:
```
 sudo apt-get install libarmadillo-dev
```

On debian it was necessary to use backports:

    sudo apt-get -t jessie-backports install libarmadillo-dev

If that is not possible, compile the provided code:

    cd phyx/deps
    tar -xvzf armadillo-7.400.2.tgz
    cd armadillo-7.400.2
    ./configure
    make
    sudo make install

Finally, install phyx:

 cd phyx/src
 ./configure
 make
 python run_tests.py

If you want to install it so it is available anywhere in your system, do:

    sudo make install

resurgo-genetics / phyx

Installation instructions

Mac install

Install with Homebrew (simple instructions)

Install with HPC GCC (advanced instructions)

Linux install

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