Python API Wrappers
APIs aren't easy to use. APIs with Python are easy to use.
So, here's a list:
Hacker News: https://github.com/avinassh/haxor
GitHub: https://github.com/PyGithub/PyGithub
Twitter: https://github.com/bear/python-twitter
Facebook: https://github.com/mobolic/facebook-sdk
Stack Overflow: https://github.com/lucjon/Py-StackExchange