Drug efficacy targets, indications, and pharmacologic class
##Data tables
###Drug target table
| Field | Description |
|---|---|
| DRUG_ID | unique identifier assigned to each active ingredient |
| CHEMBL_ID | ChEMBL database assigned identifier |
| DRUG_NAME | WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/ |
| TARGET_NAME | protein(s) name |
| TARGET_FAMILY | high level target classification (GPCR, Enzyme, Ion Channel, Transporter, Nuclear Receptor, etc.) |
| UNIPROT | Uniprot (http://www.uniprot.org/) accessions for protein targets, multicomponent targets and protein family targets list all Uniprot accessions |
| GENE | gene symbol according to HUGO (http://www.genenames.org/) |
| ACTION_TYPE | type of modulatory action exerted by drug on protein target |
| SOURCE | source of mechanism of action annotation |
| REFERENCE | reference for source URL or publication reference |
###Drug indication table
| Field | Description |
|---|---|
| DRUG_ID | unique identifier assigned to each active ingredient |
| DRUG_NAME | WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/ |
| INDICATION_FDB | drug indication extracted from OMOP v4 http://archive-omop.fnih.org/CDMvocabV4 |
| UMLS_CUI | UMLS concept unique identifier http://www.nlm.nih.gov/research/umls/ |
| SNOMEDCT_CUI | SNOMED-CT concept unique identifier http://www.nlm.nih.gov/research/umls/Snomed/snomed_main.html |
| DOID | Disease Ontology identifier http://disease-ontology.org/ |
###Pharmacologic class table
| Field | Description |
|---|---|
| DRUG_ID | unique identifier assigned to each active ingredient |
| DRUG_NAME | WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/ |
| TYPE | type according to source: FDA - Mechanism of Action (MOA), Physiologic Effect (PE), Chemical Structure (CS), and FDA Established Pharmacologic Class (EPC), MeSH - Pharmacological Action (PA), CHEBI - application (has role) |
| CLASS_SOURCE_ID | class identifier provided by source |
| CLASS | pharmacologic class |
| SOURCE | source of classification: MeSH http://www.nlm.nih.gov/mesh/pa_abt.html, FDA http://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm, and CHEBI https://www.ebi.ac.uk/chebi/ |
###Drug identifiers table
| Field | Description |
|---|---|
| DRUG_ID | unique identifier assigned to each active ingredient |
| DRUG_NAME | WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/ |
| ID_TYPE | external resource |
| IDENTIFIER | identifier in external resource |
###Identifier type table
| Field | Description |
|---|---|
| ID_TYPE | unique identifier type name in identifier table |
| DESCRIPTION | description of external resource |
| URL | external resource URL |
###LINCS Mappings
| Field | Description |
|---|---|
| SMILES | SMILES code for LINCS compounds |
| DRUG_ID | unique identifier assigned to each active ingredient |
| SM_LINCS_ID | LINCS compound id |
| DRUG_NAME | WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/ |
###Updates (11/15/2016) Data in this repository can be also downloaded from DrugCentral. Data in this repository will not be updated, please refer to DrugCentral for updates and changes.