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Optimising the design of buffer preparation in bioprocessing facilities

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dissertation

Optimising the design of buffer preparation in bioprocessing facilities

This dissertation introduces a method for selecting the optimal size and number of buffer preparation vessels required for a large-scale bioprocessing facility, given data on cycle time, buffer volumes, and data on when the buffers are required.

The problem is solved using Mixed Integer-Linear Programming (MILP). The model is constructed in Python, and uses the PuLP library used to interface with MILP solver(s).

This dissertation thesis is being undertaken as part fulfilment of the requirements of the degree of Master of Science in Business Analytics at University College Dublin.

Acknowledgements

All code in this repository is my own, with the exception of the contents of the tex folder. All files in the tex folder are based on a template created by Sean McGarraghy provided to students as part of the MIS40750 module.

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Optimising the design of buffer preparation in bioprocessing facilities

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