morrislab / crc-dtp-ith-analysis

Pipeline for evaluating intratumor genetic heterogeneity in colorectal cancer patients. Used in paper at https://www.cell.com/cell/fulltext/S0092-8674(20)31535-X.

Home Page:https://www.cell.com/cell/fulltext/S0092-8674(20)31535-X

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Description

This repository contains Pairtree input files and analysis script for "Colorectal cancer cells possess an equipotent capacity to enter a reversible diapause-like state to survive chemotherapy" with Sumaiyah Rehman, ..., Catherine O'Brien.

Jeff Wintersinger performed this analysis.

Inputs

inputs.nocna.separated: input files split into separate samples, containing only mutations from diploid regions for each sample individually

inputs.nocna.combined: input files split into separate samples, containing only mutations from the intersection of diploid regions across samples. Mutations absent from a sample are given zero variant reads, and a total number of reads corresponding to however many reads were present at that genomic locus.

About

Pipeline for evaluating intratumor genetic heterogeneity in colorectal cancer patients. Used in paper at https://www.cell.com/cell/fulltext/S0092-8674(20)31535-X.

https://www.cell.com/cell/fulltext/S0092-8674(20)31535-X


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