Package GraphMM performs multiple hypothesis testing using graph-based mixture model, which take advantage of clustering pattern to improve testing power.
Read about GraphMM https://github.com/tienv/GraphMMproject/tree/master/paper_biostat/GraphMM.pdf
library(devtools)
install_github(repo = "tienv/GraphMM", build_opts = c("--no-resave-data"))
library(GraphMM)
help(package = GraphMM)
remove.packages('GraphMM')