Nimfa
Nimfa is a Python module that implements many algorithms for nonnegative matrix factorization. Nimfa is distributed under the BSD license.
The project was started in 2011 by Marinka Zitnik as a Google Summer of Code project, and since then many volunteers have contributed. See AUTHORS file for a complete list of contributors.
It is currently maintained by a team of volunteers.
[News:] Scikit-fusion, collective latent factor models, matrix factorization for data fusion and learning over heterogeneous data.
[News:] fastGNMF, fast implementation of graph-regularized non-negative matrix factorization using Facebook FAISS.
Important links
- Official source code repo: https://github.com/marinkaz/nimfa
- HTML documentation (stable release): http://ai.stanford.edu/~marinka/nimfa
- Download releases: http://github.com/marinkaz/nimfa/releases
- Issue tracker: http://github.com/marinkaz/nimfa/issues
Dependencies
Nimfa is tested to work under Python 2.7 and Python 3.4.
The required dependencies to build the software are NumPy >= 1.7.0, SciPy >= 0.12.0.
For running the examples Matplotlib >= 1.1.1 is required.
Install
This package uses setuptools, which is a common way of installing python modules. To install in your home directory, use:
python setup.py install --user
To install for all users on Unix/Linux:
sudo python setup.py install
For more detailed installation instructions, see the web page http://ai.stanford.edu/~marinka/nimfa.
Alternatively, you may also install this package using conda:
conda install -c conda-forge nimfa
Use
Run alternating least squares nonnegative matrix factorization with projected gradients and Random Vcol initialization algorithm on medulloblastoma gene expression data:
>>> import nimfa
>>> V = nimfa.examples.medulloblastoma.read(normalize=True)
>>> lsnmf = nimfa.Lsnmf(V, seed='random_vcol', rank=50, max_iter=100)
>>> lsnmf_fit = lsnmf()
>>> print('Rss: %5.4f' % lsnmf_fit.fit.rss())
Rss: 0.2668
>>> print('Evar: %5.4f' % lsnmf_fit.fit.evar())
Evar: 0.9997
>>> print('K-L divergence: %5.4f' % lsnmf_fit.distance(metric='kl'))
K-L divergence: 38.8744
>>> print('Sparseness, W: %5.4f, H: %5.4f' % lsnmf_fit.fit.sparseness())
Sparseness, W: 0.7297, H: 0.8796
Cite
@article{Zitnik2012,
title = {Nimfa: A Python Library for Nonnegative Matrix Factorization},
author = {Zitnik, Marinka and Zupan, Blaz},
journal = {Journal of Machine Learning Research},
volume = {13},
pages = {849-853},
year = {2012}
}
Selected publications (Methods)
- Data fusion by matrix factorization: http://dx.doi.org/10.1109/TPAMI.2014.2343973
- Jumping across biomedical contexts using compressive data fusion: https://academic.oup.com/bioinformatics/article/32/12/i90/2240593
- Survival regression by data fusion: http://www.tandfonline.com/doi/abs/10.1080/21628130.2015.1016702
- Gene network inference by fusing data from diverse distributions: https://academic.oup.com/bioinformatics/article/31/12/i230/216398
- Fast optimization of non-negative matrix tri-factorization: https://doi.org/10.1371/journal.pone.0217994
Selected publications (Applications)
- A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family: https://www.nature.com/articles/s41467-017-01642-w
- Gene prioritization by compressive data fusion and chaining: http://dx.doi.org/10.1371/journal.pcbi.1004552
- Discovering disease-disease associations by fusing systems-level molecular data: http://www.nature.com/srep/2013/131115/srep03202/full/srep03202.html
- Matrix factorization-based data fusion for gene function prediction in baker's yeast and slime mold: http://www.worldscientific.com/doi/pdf/10.1142/9789814583220_0038
- Matrix factorization-based data fusion for drug-induced liver injury prediction: http://www.tandfonline.com/doi/abs/10.4161/sysb.29072
- Collective pairwise classification for multi-way analysis of disease and drug data: https://doi.org/10.1142/9789814749411_0008
Tutorials
- Hidden Genes: Understanding cancer data with matrix factorization, ACM XRDS: Crossroads: https://dl.acm.org/citation.cfm?id=2809623.2788526 [Jupyter Notebook]
