M.J. van Esdonk (Axiaal Data Analytics)'s repositories
PMX_Simulations
Simulating pharmacokinetic profiles in R (Shiny) - based on mrgsolve
PK_Parameters
Simulate an oral pharmacokinetic profile based on the dose and model parameters. Profiles can be saved in a session to explore the profiles of different parameters sets
PK_therapeutic_window
Based on a range of model parameters covering both intravenous and oral administration, simulate a multiple dose pharmacokinetic profile and calculate the time within the pre-specified therapeutic window at steady state.
PK_therapeutic_window_and_variability
Based on a range of model parameters covering both intravenous and oral administration, simulate a multiple dose pharmacokinetic profile and calculate the time within the pre-specified therapeutic window at steady state. The CV% (inter-individual variability) on the clearance and volume of distribution parameter can be modified.