Date of publication - 2019-10-07
Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women.
All summary statistcs are available on the data.bris website.
Manhattan plot of a GWAS of self-reported glycosuria in the third trimester of pregnancy in ALSPAC
We conducted a genome-wide association study (GWAS) of glycosuria (sugar
in urine) in pregnant mothers from the Avon Longitudinal Study of
Parents and Children (ALSPAC). Due to a lack of available external data
sources replication was not possible, instead we performed a GWAS in the
Northern Finland Birth Cohort 1986 (NFBC1986) where we used mothers
phenotype and the mothers’ offsprings genotype. To estimate the maternal
effects from offspring genotypes we doubled the effect estimates and
standard errors of the GWAS results (see:
PMID 27029810,
PMID 29030599,
PMID 9778168). The
manuscript and all figures, tables and supplementary information are in
manuscript.
In order to reproduce this analysis you will need access to ALSPAC and NFBC1986.
All scripts used for this work are in
scripts:
- All of the scripts use relative file paths (
./my/file/path) - This work was performed using a Mac, and scripts were run on the University of Bristol High Performance Computer, BlueCrystal 3
The script used to perform reviewer requested additional analysis is in scripts in the reviewer_analysis.