leeshawn / iECAT

Integrating external controls into association test

iECAT R-package

iECAT is an R-package for a method to integrating external controls in rare variant tests. It has functions for gene-based tests, including SKAT, and SKAT-O, and single variant test.

Link

• iECAT CRAN: Link

Recommended Controls

• Michigan Genomics Initiative Link
• UK Biobank Link
• NHLBI Exome Sequencing Project (ESP) Link

Reference

• Lee, S., Kim, S., & Fuchsberger, C. (2017). Improving power for rare‐variant tests by integrating external controls. Genetic epidemiology, 41(7), 610-619.