# HIMA2
This is the main function to estimate and testing high-dimensional mediation effects in omic studies.
# simHIMA2
This includes the R codes to generate simulation data for high-dimensional mediation analysis.
# Sample
This is a sample to generate simulation data and run high-dimensional mediation analysis.
The results are shown as follows:
M alpha alpha_SE beta beta_SE alpha.beta p_val
1 M1 0.186202499530746 0.0233729246236753 0.190685300620237 0.0539252788249321 0.0355060795992599 0.000406077463864567
2 M2 0.23760843774173 0.0254982489444596 0.275968314139476 0.0498959717919173 0.0655723999888998 3.18639839765779e-08
3 M4 0.279243031888436 0.0237937624126595 0.330119236231144 0.0527676507773055 0.0921834964098794 3.94745935005543e-10
4 M5 0.314394446452975 0.0244683773118442 0.398917101220018 0.0503509385909565 0.125417321218693 2.32343976532013e-15
References
Perera C, Zhang H, Zheng Y, Hou L, Qu A, Zheng C, Xie K, Liu L. HIMA2: High-dimensional Mediation Analysis and its application in epigenome-wide DNA methylation data. BMC Bioinformatics. 2022. Accepted.
Depends R (>= 3.4) hdi, HDMT, MASS