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Jim Hughes (jhhughes256)

jhhughes256

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Company:Pfizer

Location:United States

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Jim Hughes's repositories

pfe_shiny_intro

Course materials for "Introduction to Shiny" internal course given in November 2020

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azithro_pk

Web application, raw code and digitised data for published manuscript: Hughes, J.H., Sweeney, K., Ahadieh, S. and Ouellet, D. (2020), Predictions of Systemic, Intracellular, and Lung Concentrations of Azithromycin with Different Dosing Regimens used in COVID‐19 Clinical Trials. CPT Pharmacometrics Syst. Pharmacol. Application can be found at:

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nivo_sim

Raw R code used in draft manuscript: Hughes JH, Roussin-Bouchard U, Wang Y, Boddy AV, Reuter SE. Reduction of Nivolumab Dosing using Adaptive-Dosage Strategies

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otter_code

R code for manuscript: Hughes JH, Upton RN, Reuter SE, Phelps MA, Foster DJR. Optimising time samples for determining AUC of pharmacokinetic data using non-compartmental analysis. - Web App can be found at:

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acidbase_fit

Estimation of rate constant parameters for the acid/base attack of aspirin. Post-graduate work for Dr. Desmond Williams at University of South Australia.

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calc_caff

Calcium Caffeine Model Simulations. Post-graduate work for Dr. Stephanie Reuter-Lange at University of South Australia.

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comp_app

Web applications for use with compositional data. Post-graduate work for Dr. Dot Dimuid and Prof. Timothy Olds at University of South Australia.

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empir_bayes

Empirical MAP Bayes examples and applications. Post-graduate work for Dr. Stephanie Reuter-Lange at University of South Australia.

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NCAvNLME

Raw R code used in manuscript: Hughes JH, Upton RN, Foster DJR. Comparison of non-compartmental and mixed effect modelling methods for establishing bioequivalence for the case of two compartment kinetics and censored concentrations. J Pharmacokinet Pharmacodyn. 2017:1-12.

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shiny-paganz

R code of Shiny workshop presented at PAGANZ 2017 in Adelaide.

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shinyapps

Public apps and examples

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carbo_app

Dosing application for manuscript: Harris, B.D.W., Phan, V., Perera, V. et al. Inability of Current Dosing to Achieve Carboplatin Therapeutic Targets in People with Advanced Non-Small Cell Lung Cancer: Impact of Systemic Inflammation on Carboplatin Exposure and Clinical Outcomes. Clin Pharmacokinet (2020). https://doi.org/10.1007/s40262-020-00870-6 - Web App can be found at:

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len_pbpk

Raw R code for manuscript: Hughes JH, Upton RN, Reuter SE, Rozewski DM, Phelps MA, Foster DJR. Development of a physiologically-based pharmacokinetic model for intravenous lenalidomide in mice.

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LEN_PK

Raw R code used in manuscript: Hughes JH, Phelps MA, Upton RN, et al. Population pharmacokinetics of lenalidomide in patients with B-cell malignancies. Br J Clin Pharmacol. 2019;85(5):924-934.

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optinterval

Raw R code for manuscript: Hughes JH, Upton RN, Reuter SE, Phelps MA, Foster DJR. Optimising time samples for determining AUC of pharmacokinetic data using non-compartmental analysis.

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vanc_tdm

Raw R code for simulations using South Australia Health Guidelines for vancomycin dosing. Post-graduate work for Dr. Stephanie Reuter-Lange at University of South Australia.

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