czbiohub-sf / cerebra

A tool for fast and accurate summarizing of variant calling format (VCF) files

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improve germline filtering: handle multiple ALTs better

rvanheusden opened this issue · comments

I was just thinking—right now, the germline filter will only match two records if the CHROM, POS, REF, and ALT are all the same. But, since VCFs will encode all mutations that happen at a particular POS as multiple ALTs, we could instead just check if one (not all) of the ALTs match, and then remove that ALT specifically.

Implemented by 63bdeeb.