benostendorf / padmanaban_etal_2024

Custom computer code for Padmanaban et al., Nature, 2024

Substance P and breast cancer metastasis

This repository contains the code to reproduce all figures from the manuscript

Neuronal substance-P drives breast cancer growth and metastasis via an extracellular RNA-TLR7 axis, Nature, 2024

Veena Padmanaban, Isabel Keller, Ethan S. Seltzer, Benjamin N. Ostendorf, Zachary Kerner, Sohail F. Tavazoie

doi:

Overview

Analysis	Folder	Main code file
GSEA of shTlr7 versus shCtrl 4T1-derived spheroids	RNAseq_spheroids	GSEA_shTlr7_spheroids.R
Association between a TLR7-dependent signature and survival in TCGA breast cancer patients	TCGA	01_TCGA.Rmd
Association between a TLR7-dependent signature and survival in METABRIC breast cancer patients	METABRIC	01_METABRIC_Tlr7_signature.Rmd

GEO upload for RNA-seq of 4T1 spheroids (GSE267958)

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267958