ayushchopra96 / topologize

Sequence Independent Protein Structural Topology Comparison Metric

Sequence Independent Protein Structural Topology Comparison.

Distinguishing Characteristic

Runs independently of the protein primary sequence.
Subsecond performance

Input Format

Takes as input PDB files for the 2 proteins.
Store pdb data files in ./files

Setup and Execution Instructions

1. git clone https://github.com/ayushchopra96/topologize.git
   
2. cd topologize
   
3. sh generate_executable.sh
   
4. ./a.out ./path/to/pdb1 ./path/to/pdb2
   

Outputs scaled metric value for the structural topology similarity.

Metric Inference

Result Analysis:-
1. output result > 0.72 :- High level of structural similarity
2. output result < 0.45 :- No structural similarity
3. 0.72 > output > 0.45 :- Partial Structural Similarity