How is the QUAL metric calculated?

Question

flashton2003 opened this issue 4 years ago · comments

Hello,

I'm curious as to how the QUAL metric is calculated, and how it should be interpreted?

From my limited analysis, it seems that only variants with a QUAL of 999 should be taken as high quality variants. Does this seem overly stringent?

Thanks,

Phil

Ruibang Luo · Answer 1 · Fri Apr 03 2020 10:32:10 GMT+0800 (China Standard Time)

QUAL is calculated as the distance between the best and second-best result. Higher score -> larger distance -> more reliable the result is.

BTW, you might want to use the new version at https://github.com/HKU-BAL/Clair. The quality calculation is more reboust in the new version.

flashton2003 · Answer 2 · Fri Apr 03 2020 18:23:02 GMT+0800 (China Standard Time)

Thank you! I'll check out Clair.