VGpop

The aim is drive standard population genetic analyses using pangenomic data models. Typically represented in the Graphical Fragment Assembly (GFA) format, these models can represent whole genome alignments in a compact graphical structure.

I have focused on algorithms for bubble detection that allow us to generate Variant Call Format (VCF) files from graphs.

I use this projection to drive standard population genetic analyzes, and as a mechanism to validation results that I obtain from pangenome graph based population genetic analyzes which I am designing.

Component Required

ODGI

Building from GitHub odgi
Download from Bioconda odgi

Usage

Clone the source locally:

git clone https://github.com/Flavia95/VGpop.git
cd VGpop

Before run the script GfatoVcf.py, you need to:

1. Convert the GFA format to the ODGI format

By example:

odgi build -g samplePath3.gfa -o samplePath3.odgi

The odgi format as input to the script.

2. With -path specify the path of the odgi library and with -input specify the input file as odgi format

python GfatoVcf.py -path /../odgi/lib/ -input /../samplePath3.odgi

Description of the script

DescriptionGfatoVcf.md

Author

Flavia Villani

License

MIT

ambarishK / VGpop