allydunham / deepscanscape

R package for annotating deep mutational scanning data using the deep mutational landscape

DeepScanScape - Annotate deep mutational scans using the deep landscape

Process and annotate deep mutational scanning data using a deep mutational landscape derived from 28 previous studies (Dunham & Beltrao 2021), highlighting unusual properties, visualising data and assigning positions to amino acid subtypes that predict their likely features.

Installation

Install the latest version from GitHub

if (!require("devtools")) {
  install.packages("devtools")
}
devtools::install_github("allydunham/deepscanscape")

Usage

We recommend new users start with the package vignette, which shows an example analysis importing and assessing three typical deep scans. The examples in the documentation also illustrate the usage of each function. Reading the publication describing the theory behind the deep landscape may also help explain package usage.

Citation

Alistair S. Dunham & Pedro Beltrao (2021). Exploring amino acid functions in a deep mutational landscape. MSB doi: https://doi.org/10.15252/msb.202110305