abhay8154 / SCLC-Project-Code

Analysis of SCLC Cell Lines elucidates the landscape of phenotypic heterogeneity enabling diverse SCLC subtypes.

Small Cell Lung Cancer (SCLC)

Computational analysis reveals similarities and differences between SCLC subtypes

Datasets CCLE, GSE73160, GSE7097, GSE10841, GSE45120, GSE62609, GSE66294 & GSE144457 need to be downloaded into the "Datasets" folder. In case of multiple probes, for microarray data, median expression was considered.

ssGSEA scores were generated using the ssgsea-gui.R script available here

Note: Use Transcripts Per Million (TPM) noramalized RNA-seq dataset for ssGSEA

Programming languages used in this analysis

R version 4.0.4 

Bioconductor version 3.11

Python version 3.8.3

Contact

For questions regarding the code deposited in this repository, please reach out to Abhay Singh via email at: ssabhay6 [at] gmail [dot] com