The Structural Genomics Consortium's repositories
CNP18-DENVRdrp-VirtualScreen
An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on the results from a virtual screening campaign of the Enamine REAL space to identify hits. Use the link below to learn about other READDI-AViDD projects.
CNP24-NSP10_14-Frags
This project aims to develop potent inhibitors of NSP14/NSP10 for the treatment of (CoV-19), Targeting the NSP14 and NSP10 interacting interface with small molecules or peptides could be a smart strategy to obstruct replication processes of coronaviruses (CoVs).
CNP25-CHIKV-nsP3-Macrodomain
This project aims to develop a chemical probe of CHIKV-nsP3-macrodomain starting from a fragment screen
CNP10-CHIKV-Naphthoquinone
An Open Chemistry Network dedicated to finding hits vs CHIKV based on a hit containing an naphthoquinone.
CNP12-Nsp15-TAMU
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CNP17-DENVRdrp-EnamineCovalent
An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the Enamine covalent library. Use the link below to learn about other READDI-AViDD projects.
CNP19-CHIKVhelicase-Covalent
An SGC Open Chemistry Networks Project (number 19) dedicated to finding hits vs CHIKV nsp2 helicase based on a HTS of a Enamine Covalent library.
CNP20-CHIKVhelicase-VirtualScreen
An SGC Open Chemistry Networks Project (number 20) dedicated to finding hits vs CHIKV nsp2 helicase based on a Virtual Screen of Enamine REAL compounds.
CNP21-CHIKVhelicase-Asinex
An SGC Open Chemistry Networks Project (number 21) dedicated to finding hits vs CHIKV nsp2 helicase based on a HTS of a Asinex library.
CNP8-Nsp13-Indoles
An Open Chemistry Network dedicated to finding hits vs SARS-CoV-2 Nsp13 based on a hit containing an indole.
CNP11-DENVRdrp-LifeChem
An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the LifeChemicals library. Use the link below to learn about our other READDI-AViDD projects.
CNP22-CHIKV-Nsp2-Protease
This project aims to develop new CHICKV NSP2 protease inhibitors with high potency and selectivity as well as with an improved physicochemical properties.
CNP26_DENVRdrp_ReferenceCmpds
An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on identifying a DENV reference compound. If you would like to learn about other repositories in the READDI-AViDD pipeline, please use the link below.
CNP27-SARS-CoV-2-NSP14
This project aims to develop a chemical probe of SARS-CoV2-NSP14 starting from a fragment screen
CNP29_CHIKVnsp2_DEL-ML
An SGC Open Chemistry Networks Project (number 29) dedicated to finding hits vs CHIKV nsp2 helicase based on a DEL screen and subsequent machine learning by X-Chem.
CNP32_SARS-CoV-2_nsP13-Helicase_thiazoles
SARS-CoV-2 NSP13 helicase inhibitors development campaign based on pritelivir
CNP33_SARS-CoV-2_nsP12-RdRp_HTS
SARS-CoV-2 nsP12 RdRp inhibitor development campaign by HTS
CNP34_SARS-CoV-2_nsP13-Helicase_cheminformatics
SARS-CoV-2 nsP13 helicase inhibitors identification through data mining
CNP7-RdRp-S1-Tetrazole
An Open Chemistry Networks Project Targeting SARS-CoV-2 RdRp
CNP9-DENVRdrp-ChEMBL
An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the ChEMBL database. Please use the link below to view all projects in the READDI-AViDD pipeline.