Transmission of signals at nerve cell terminals requires a complex sequence of interactions. One result is the docking of vesicles containing neurotransmitter at a specialized region of the cell membrane called the active zone. In a simple 2D Cell-DEVS, a fundamental sequence has been modeled which includes (i) opening of calcium ion channels, (ii) activation of calmodulin by calcium ions, (iii) activation of calcium-calmodulin-dependent protein kinase II by activated calmodulin, (iv) phosphorylation of synapsin by activated kinase and (v) release of synaptic vesicles held in a cluster by synapsin.
Transmission of signals at nerve cell terminals requires a complex sequence of interactions. One result is the docking of vesicles containing neurotransmitter at a specialized region of the cell membrane called the active zone. In a simple 2D Cell-DEVS, a fundamental sequence has been modeled which includes (i) opening of calcium ion channels, (ii) activation of calmodulin by calcium ions, (iii) activation of calcium-calmodulin-dependent protein kinase II by activated calmodulin, (iv) phosphorylation of synapsin by activated kinase and (v) release of synaptic vesicles held in a cluster by synapsin.