This file provides data and main codes for performing time-stratified case-crossover analyses presented in the published paper: Xu R, Xiong X, Abramson MJ, Li S, Guo Y. Association between ambient temperature and sex offense: A case-crossover study in seven large US cities, 2007–2017. Sustainable Cities and Society 2021;69:102828. https://doi.org/10.1016/j.scs.2021.102828