This BOF can be used to identify processes that hold handles to a given file. This can be useful to identify which process is locking a file on disk.
I have found that x86 beacons will crash sometimes when attempting to enumerate handles associated with an x64 image. For example, running enumhandles c:\windows\sysnative\svchost.exe may cause a crash.
All credit for this technique belongs to Grzegorz Tworek:
The specific tweet regarding this technique can be found here.