Nheyer / linkage_calc

A C++ program that utilizes gametic linkage disequilibrium, permutation tests, and bootstrapping to calculate linkage from a multi-sample gvcf

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linkage_calc

Source files to create linkage calc, a program that determines if haploid samples in a multi-sample vcf have alleles that are linked, by using a gamitic linkage calculation then permitation tests. Developed initioly for use with the NOTCH2NL genes, but is fully generalized.

Installation: make sure you have the required dependincies for htslib (pthread lzip)

make sure you have cmake 3.10.0 or higher installed

run the command "cmake CMakeLists.txt && make "

then move the binary "linkage" into your path.

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A C++ program that utilizes gametic linkage disequilibrium, permutation tests, and bootstrapping to calculate linkage from a multi-sample gvcf

License:GNU General Public License v3.0


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