This repository provides the MATLAB scripts for our quantitative systems pharmacology model published in Front. Bioeng. Biotechnol., where we conduct an in silico clinical trial in breast cancer using anti-PD-1, anti-CTLA-4 antibody and an epigenetic modulator.
To initiate the model, run /sciprts/immune_oncology_model.m All parameters are defined in /model/default_parameters_TNBC.m Parameters and reactions for each species are read and added into the model by each module in /model
To run in silico clinical trials, use /sciprts/PSA_script_HW.m Parameter ranges and distributions from which virtual patients are drawn are defined in /postprocessing/PSA_param_in_HW.m
For further questions, please contact the author: Hanwen Wang, hwang163@jhmi.edu
This repository provides the MATLAB scripts for our quantitative systems pharmacology model published in Front. Bioeng. Biotechnol., where we conduct an in silico clinical trial in breast cancer using anti-PD-1, anti-CTLA-4 antibody and an epigenetic modulator.
https://doi.org/10.3389/fbioe.2020.00141