DBinary / GBM_spatial

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GBM_spatial

To do list:

Profiling

  • scRNA-seq annotation
  • show known marker expression in each cluster
  • Spatial intergration + clsutering
  • Spatial Deconvolution
  • Correlation between deconvolution weight and celltype fraction

Hypoxic

  • scRNA-seq hypoxic Macrophage: deg, enrichment
  • Spatial hypoxic region seg
  • DEGs and enrichment between hypoxic region and normal region in seg region
  • CCC for hypoxic tumor and all macrophage in seg region
  • Macrophage trajectory (velocity) in seg region

Blood vessel

  • Clustering define blood vessel
  • immu cell decon weight in & out blood vessel
  • blood vessel B/T deg & enrichment
  • scRNA-seq exhausted score for immu cell in blood vessel
  • statistic test for Pathway score of in & outr blood vessel T/DC

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