This the the simplest handler for an Alexa Skill using Zappa and Flask that I've been able to put together.
I was having a nightmare getting flask-ask to behave with Python3 and Zappa so came up with this to get me moving. Hopefully it's useful for someone else.
For anyone wondering, I was getting a NoneType error whenever I importing the Ask library from flask-ask.
For full instructions please see Zappa's GitHub page. Their instructions are awesome.
For a quick example, assuming you've configured your lambda credentials: you need to setup your virtual environment, attatch yourself to it, install the required python packages and then run zappa...
virtualenv venv
source venv/bin/activate
pip install -r requirements.txt
zappa init
zappa deploy dev
Here's some of the tutorials I was following to get this far: