zwdzwd / sesame

🍪 SEnsible Step-wise Analysis of DNA MEthylation BeadChips

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Is sesame modeling beta or log(beta/(1-beta))?

alanlamsiu opened this issue · comments

Hi @zwdzwd,

I remember seeing the details of how sesame models beta using covariates before but I couldn't find the related information recently. I am trying to understand whether sesame is doing beta ~ beta0 + beta1 x covariate1 or log(beta/(1-beta)) ~ beta0 + beta1 x covariate1, assuming only covariate1 is the only covariate.

Thanks.

just beta, the default modeling doesn't use M -value. I think one could transform manually if needed.