Install protoc compiler from apt repository sudo apt install protobuf-compiler Install python packages to genrate python packages from .proto file pip install grpcio grpcio-tools Install python packages to genrate python packages from .proto file go get -u google.golang.org/grpc go get -u github.com/golang/protobuf/proto go get -u github.com/golang/protobuf/protoc-gen-go Genrate go package from .proto file with grpc extension protoc --go_out=plugins=grpc:. models/calculator.proto Genrate python package from .proto file with grpc package support python -m grpc_tools.protoc -I. --python_out=. --grpc_python_out=. ./models/calculator.proto