This describes how to build the software for 64 bit Windows, on Windows itself. Install MSYS (http://www.mingw.org/wiki/MSYS). (I tested 1.0.11, the last standalone MSYS.) Do NOT install MinGW (it does not have a 64 bit compiler at the time of this writing). Change the default install directory to c:/msys64. This has two advantages: 1. if you already have MSYS/MinGW installed, this does not conflict, and you get a clean 64 bit build environment 2. if in some months you want to install a standard 32-bit MinGW, you will not get surprised by incompatible 64 bit libraries Install a 64 bit toolchain from http://win-builds.org/download.html Configure it "for MSYS" (in the MSYS shell, run: yypkg-1.4.0.exe --deploy --host msys) Install any variant of cmake (http://www.cmake.org/download/). The binary x86 package is fine and will also work. CMake is needed to build some of the needed libraries. It is a good idea to let the installer add CMake to system PATH (current or all users doesn't matter, though) In the MSYS console window, run ". /opt/windows_64/bin/win-builds-switch 64" before running anything else, this makes the 64 bit toolchain available to MSYS. Build and install gdcm (http://sourceforge.net/projects/gdcm/). Create a separate directory gdcm-build that is NOT inside the gdcm-2.4.3 source tree, and run: cmake -G "MSYS Makefiles" -DGDCM_BUILD_SHARED_LIBS=ON -DCMAKE_INSTALL_PREFIX:PATH=/ ../gdcm-2.4.3 Build and install glew (http://glew.sourceforge.net/). Build and install glfw (http://www.glfw.org/). Not needed if you do not need the glview application (or if I forgot to update this document and there is no glview anymore). run: cmake -G "MSYS Makefiles" -DBUILD_SHARED_LIBS=ON -DCMAKE_INSTALL_PREFIX:PATH=/ . Install the 64 bit Python 3 package (https://www.python.org/downloads/windows/). It is likely that you do not have the xxd tool available. If you get errors about it while building it, it is in the Vim source code. Download the source (http://www.vim.org/sources.php), go to src/xxd, run make && cp xxd.exe /bin You might need to create mf/local with something like this: PYTHON = c:/python34/python GDCM_INCLUDE = -I/include/gdcm-2.4 LOCAL_LIB_PATHS = -L/bin -L/lib LOCAL_INCLUDES = -I/include You should be able to build the complete project tree now. As Windows doesn't support the ifunc mechanism (runtime detection of CPU features and replacing functions _transparently_) and I was too lazy to rewrite it to function pointers hidden behind macros (or so), on Windows in general the version to use is determined at compile time - with your help. Interesting options (preprocessor macros) are: BUILD_SSE2, BUILD_MMX When building for 64 bit Windows, both can be enabled, as MMX and SSE2 are always available in x86_64. Note that the build system is set to -march=native by default and GCC may decide to create code that doesn't run anywhere but on your own box. Edit it if you dislike this (or wait for a fix)