NxNiki / multidimensional_age_prediction

multidimensional_age_prediction

1. run quadratic regression on brain features with age, age^2, sex, agesex, and age^2sex
2. run cluster analysis based on the coefficients in the regression model.
3. build age prediction model for each cluster identified in the previous stage.
4. examine how the predicted age (brain age), and brain age gap (chronological age - brain age) is associated with behavioral performance and disorder

For details, see our publication:

Xin Niu, Alexei Taylor, Russell T Shinohara, John Kounios, Fengqing Zhang, Multidimensional Brain-Age Prediction Reveals Altered Brain Developmental Trajectory in Psychiatric Disorders, Cerebral Cortex, 2022;, bhab530, https://doi.org/10.1093/cercor/bhab530