Can AlphaFold2 predict the structure of cyclic peptides?
JustinDoIt opened this issue · comments
I have a cyclic peptide sequence. I put it into Alphafold2 Colab, but I didn't get a cyclic peptide structure. What should I do to connect the C-terminal and N-terminal for the next dynamic simulation (GROMACS)?
Should I do some processing on the structure obtained by Alphafold2 Colab for Gromacs dynamics? Or input sequence to Alphafold2 Colab need for some pre-processing? Or can Alphafold2 not predict the sequence of cyclic peptides?
It's really important for my research, thanks for any help.
sorry, I do not know how to make cyclic peptide model. I have not done such thing before.
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签名由网易邮箱大师定制
On 9/8/2021 22:57，Jianqi ***@***.***> wrote：
I have a cyclic peptide sequence. I put it into Alphafold2 Colab, but I didn't get a cyclic peptide structure. What should I do to connect the C-terminal and N-terminal for the next dynamic simulation (GROMACS)?
Should I do some processing on the structure obtained by Alphafold2 Colab for Gromacs dynamics? Or input sequence to Alphafold2 Colab need for some pre-processing? Or can Alphafold2 not predict the sequence of cyclic peptides?
It's really important for my research, thanks for any help.
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